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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosisA total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followedCompared with the patients without cirrhosis, the patients progressed to cirrhosis were older and withHowever, there was no significant difference in cirrhosis progression between different HBV-DNA groupsKaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis ( = 0.019

Keywords： hepatitis B     chronic     viral load     liver cirrhosis    

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Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 421-427 doi: 10.1007/s11684-012-0223-5

Abstract:

In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patientsThe clinical data of 48 cirrhosis patients with 60 normal controls and 39 ALF patients were collectedThe hepatic volume of cirrhosis patients in Child A, B level was not reduced, but in Child C level itIn conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liverfunction and progression of cirrhosis and ALF.

Keywords： liver volume variation     cirrhosis     acute liver failure (ALF)    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Characterization of the Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations Article

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Engineering 2021, Volume 7, Issue 4,   Pages 507-514 doi: 10.1016/j.eng.2020.04.014

Abstract: Several studies have indicated that the oral and gut microbiota may exhibit differences in patients with cirrhosisIn this study, the gastric mucosal microbiota of patients with liver cirrhosis and controls were analyzedIn H. pylori-negative subjects, gastric bacterial communities of healthy and cirrhosis cohortssuggest that the colonization of both H. pylori and non-H. pylori is influenced in livercirrhosis.

Keywords： Microbiome     Liver cirrhosis     Symptoms     Varices     Gastric endoscopy    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate cells

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: This study aims to investigate the influence of β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptor type 1 (AT1R) in hepatic stellate cells (HSCs). , HSC-T6 were cultured for 24 hours and then treated with different doses of β-elemene (2.5, 5 and 10 mg/L). A control group was also set up. The secretion of ANG II in the supernatant was detected by radioimmunoassay. The mRNA expression of AT1R at 4, 12 and 24 h after treatment was detected by reverse transcription-polymerase chain reaction (RT-PCR), respectively. The protein expression of AT1R was detected by western blot. At the 4th h, the ANG II secretion in the supernatant was significantly inhibited by 10 mg/L β-elemene compared with the control group ( <0.05), while 5.0 mg/L and 2.5 mg/L β-elemene had no inhibitory effect on the secretion of ANG II ( >0.05). At the time point of the 12th h, the secretion of ANG II in the supernatant treated with 10 mg/L and 5.0 mg/L β-elemene was significantly lower than the control ( <0.01, <0.05). Following the treatment with 5.0 mg/L and 2.5 mg/L β-elemene for 24 h, significant inhibition of ANG II secretion was observed ( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1R mRNA in HSCs after the treatment for 4, 12, and 24 h in a dose-dependent manner. The expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene can inhibit the secretion of ANG II and the gene and protein expression of AT1R, which may be the mechanism by which β-elemene prevents the progress of hepatic fibrosis.

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 255-263 doi: 10.1007/s11684-012-0227-1

Abstract:

The efficacy of ursodeoxycholic acid (UDCA) on long-term outcome of primary biliary cirrhosis (PBC

Keywords： primary biliary cirrhosis     ursodeoxycholic acid     Chinese     biochemical response     therapeutic efficacy    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats

LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 39-44 doi: 10.1007/s11684-008-0008-z

Abstract: The liver fibrogenesis was assessed using a digital image analysis instrument of Masson’s trichrome stainedThe expression of liver regeneration-related protein LRRG03 and vimentin increased in the cirrhotic modelproteins related to oxidative stress, cell proliferation and transformation have changed in the plasma of cirrhosis

Keywords： Decoction intervention     serine/threonine-protein     underwent     Decoction     glutathione peroxidase    

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Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated

Guanghua Rong,Wenlin Bai,Zheng Dong,Chunping Wang,Yinying Lu,Zhen Zeng,Jianhui Qu,Min Lou,Hong Wang,Xudong Gao,Xiujuan Chang,Linjing An,Yan Chen,Yongping Yang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 63-71 doi: 10.1007/s11684-014-0342-2

Abstract:

Cryoablation is a less prevalent percutaneous ablative therapy for hepatocellular carcinoma (HCC), and current evidence about its usefulness is limited. We report our experience in treating 1595 HCC cases with percutaneous cryoablation to give a comprehensive profile about the effectiveness, safety and long-term outcome of this therapy. From January 2003 to December 2013, 1595 patients with 2313 HCC nodules were ablated with 2945 cryoablation sessions in our center. Complete ablation was achieved in 1294 patients for 1893 nodules with a mean diameter of 3.4±2.2 cm. The complete ablation rate was 81.2%, 99.4%, 94.4%, and 45.6% in all tumors, tumors<3 cm, tumors<5 cm, and tumors>5 cm, respectively. Major complications were observed after 80 (3.4%) of the 2945 cryoablations and minor complications were observed after 330 cryoablations with no treatment-related deaths. After a median follow-up of 33.4 months, 937 patients developed different types of recurrence. The 5- and 10-year overall survival was 25.7% and 9.2%, respectively. Cryoablation showed reliable safety and efficacy and should be considered as a promising technique, particularly when a large zone of ablation is required.

Keywords： hepatocellular carcinoma     percutaneous cryoablation     efficacy     safety    

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The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 495-505 doi: 10.1007/s11684-020-0790-9

Abstract: explore the effect and mechanisms of the treatment plan of “traditional Chinese medicine (TCM) regulating liverA total of 457 patients with HBV-related liver failure were retrospectively collected.In addition, there were significant differences in the expression of several cytokines related to liverRLR treatment can decrease jaundice, improve liver function, and significantly reduce the mortality inpatients with HBV-related liver failure.

Keywords： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration    

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Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 123-129 doi: 10.1007/s11684-017-0563-2

Abstract:

Liver transplantation is a conventional treatment for terminal stage liver diseases.Intestinal barrier destruction is widely observed among patients receiving liver transplant and sufferingThis article reviews the research progress for gut microbial alterations and liver transplantation.microbial alteration and the prediction of possible injuries utilizing microbial alteration during liverand offer a hypothesis on the utilization of microbial alteration in liver transplantation.

Keywords： gut microbial balance     liver transplantation     ischemia–reperfusion     acute rejection    

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract:

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simplesteatosis to advanced pathologies, including nonalcoholic steatohepatitis and cirrhosis.steatosis, which is characterized by excessive accumulation of triglyceride-rich lipid droplets in the liverAccumulating evidence supports that dysregulation of adipose lipolysis and liver de novo&

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

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Overview on acute-on-chronic liver failure

Jing Zhang,Shan Gao,Zhongping Duan,Ke-Qin Hu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 1-17 doi: 10.1007/s11684-016-0439-x

Abstract:

Liver failure (LF) is defined as severe dysfunction in hepatic synthesis, detoxification, and metabolism

Keywords： liver failure     chronic liver failure     acute-on-chronic liver failure     diagnosis     prognosis     treatment    

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Title Author Date Type Operation

Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Journal Article

Assessment of liver volume variation to evaluate liver function

Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Characterization of the Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate cells

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Effects of Decoction on plasma proteome in cirrhosis: preliminary experimental study with rats

LIU Jie, WANG Jiyao, WEI Liming, LU Ye, Jin Hong

Journal Article

Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated

Guanghua Rong,Wenlin Bai,Zheng Dong,Chunping Wang,Yinying Lu,Zhen Zeng,Jianhui Qu,Min Lou,Hong Wang,Xudong Gao,Xiujuan Chang,Linjing An,Yan Chen,Yongping Yang

Journal Article

The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

Journal Article

Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

Overview on acute-on-chronic liver failure

Jing Zhang,Shan Gao,Zhongping Duan,Ke-Qin Hu

Journal Article